A Free Online CME Course for Medical Professionals

Pain management is evolving, and medical professionals need to be aware of current guidelines and clinical best practices. The new NEJM Knowledge+ Pain Management and Opioids CME course enhances your knowledge about opioids, so you can feel more confident managing pain appropriately. The new CME course is offered FREE to medical professionals.

To claim your CME credits, you must answer all 62 case-based questions. Once you have seen the completion pop-up message, you can go to the MOC/CME or Accreditation Center within the product to download a transcript of your credits.


This course covers:

FDA Opioid Analgesic REMS Education Blueprint for Health Care Providers
Involved in the Treatment and Monitoring of Patients with Pain

Over 60 case-based questions with feedback and resources

Pain Management and Opioids CME increases your knowledge of:

  • The latest practices for assessing and managing acute and chronic pain.
  • Current guidelines in the appropriate use of opioids for pain management.
  • Evidence-based strategies for recognizing and treating opioid use disorder.

Pain Management CME: The NEJM Knowledge+ Difference

Clinicians value NEJM Knowledge+ for more than earning CME and MOC. It has been proven to help them pass their board exams, engage in lifelong learning, and improve their confidence and clinical decision-making skills. The new Pain Management and Opioids CME module employs the cognitive science principles of all NEJM Knowledge+ programs to give you the same trusted learning outcomes.

Content created by clinicians, for clinicians.

As with all NEJM Knowledge+ modules, the new Pain Management and Opioids CME course contains peer-reviewed, expert content. This question bank is designed by clinicians, including pain management experts and addiction specialists, with realistic cases and engaging feedback you may experience in your daily practice. Learn today and put your knowledge to use immediately.


Engaging and efficient learning strategy.

NEJM Knowledge+ goes beyond passive reading and rote memorization by actively testing your knowledge to ensure you master the material. Unlike other educational programs that repeat the same question until it is answered correctly, NEJM Knowledge+ presents questions in a variety of formats until you achieve true mastery of the underlying concepts.


Mobile, quick, and convenient.

Available online in both desktop and mobile versions, NEJM Knowledge+ is there for you when and where you want to learn, whether during downtime in your clinic or when out of the office. Set yourself bite-sized, achievable goals of answering a few questions at a time and take advantage of the mobility of NEJM Knowledge+ to do so on your schedule. Answer questions anywhere, anytime.


Adaptive Learning Advantage

NEJM Knowledge+ encourages you to be a lifelong learner. Once you have successfully completed your Pain Management and Opioids CME requirements, you can return to the program to refresh your knowledge around safe prescribing. Our adaptive learning algorithms adjust the questions you see based on their assessment of your understanding of the material, as well as your confidence and response time, to adjust your learning pathway in real time.

What Is Adaptive Learning?

An individualized learning experience that starts by determining a learner’s strengths and weaknesses, then uses powerful algorithms to serve information and learning exercises that address limitations and guide the learner to greater proficiency.

Opioids CME: How the NEJM Knowledge+ Online Course Works

  1. Register for free.
  2. Choose either Internal Medicine or Family Medicine.
  3. Download the app from the App Store or Google Play.
  4. Begin answering questions anytime, anywhere you want.

Please note: You must answer all 62 case-based questions and review the corresponding feedback to claim your CME credits (see table below for more detail). After completing your CME requirements, you can continue to use the Pain Management and Opioids module to refresh your knowledge, as much as you want.

Obtaining Credits and Points

AMA PRA Category 1 Credits™
(earn up to 10)
(earn up to 10)
AAFP Prescribed Credits
(earn up to 10)
Automatically tracked while learningProvide your ABIM # and your Date of BirthAutomatically tracked while learning
Print your transcriptYour points are submitted for you as you earn them.
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Print your transcript
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Why You Should Register for Your FREE Online Pain Management and Opioids CME Course

We understand the pressures facing today’s medical professionals. You need to stay on top of a constantly growing and evolving body of medical knowledge to provide the best patient care. Our nation’s opioid epidemic makes the job even harder, requiring you to meet the needs of your patients while complying with requirements from regulatory and oversight organizations.

The NEJM Knowledge+ Pain Management and Opioids CME course addresses these needs and is the most efficient way to review the current, evidence-based clinical knowledge on opioid analgesics. Completing this activity will improve your knowledge about:

  • The fundamental concepts of pain management, including definitions and mechanisms of pain.
  • How to assess patients in pain, while identifying risk factors for abuse and addiction.
  • The range of therapeutic options for managing pain, including non-pharmacologic approaches and pharmacologic (non-opioid and opioid analgesics) therapies.
  • How to integrate opioid analgesics into a pain treatment plan individualized to the needs of the patient.
  • How to safely and effectively manage patients on opioid analgesics in acute and chronic pain settings, including initiating therapy, titrating, and discontinuing use of opioid analgesics.
  • How to counsel patients and caregivers about the safe use of opioid analgesics, including proper storage and disposal.
  • How to counsel patients and caregivers about the use of naloxone for opioid overdose.
  • When referral to a pain specialist is appropriate.
  • The fundamental elements of addiction medicine.
  • How to identify and manage patients with opioid use disorder.

Did You Know?

NEJM Knowledge+ Pain Management and Opioids module may also help you comply with CDC safe prescribing guidelines and state-mandated CME requirements.

Partners in medical education. The new Pain Management and Opioids modules within NEJM Knowledge+ Internal Medicine Board Review and Family Medicine Board Review are offered in partnership with Boston University School of Medicine’s Safer/Competent Opioid Prescribing Education (SCOPE of Pain) program. Thanks to an unrestricted educational grant as part of the FDA’s mandated Risk Evaluation and Mitigation Strategy (REMS) program, NEJM Knowledge+ is able to make this new CME module available for free.

Logo for BUSM SCOPE of Pain

Accreditation Information
Disclosure of support

This activity is supported by an independent educational grant from the Opioid Analgesic REMS Program Companies. Please see https://ce.opioidanalgesicrems.com/RpcCEUI/rems/pdf/resources/List_of_RPC_Companies.pdf for a listing of REMS Program Companies. This activity is intended to be fully compliant with the Opioid Analgesic REMS education requirements issued by the US Food and Drug Administration.

Accreditation Statement

The Massachusetts Medical Society is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

AMA Credit Designation Statement

The Massachusetts Medical Society designates this enduring material for a maximum of 10 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Risk Management and Pain Management Credits

This activity meets the criteria of the Massachusetts Board of Registration in Medicine for risk management study.

This activity meets the criteria of the Massachusetts Board of Registration in Medicine for opioid education.

Many states have similar requirements. Please check with your Board to determine if this activity will fulfill your state's specific requirements.

American Board of Internal Medicine MOC Points
NEJM Knowledge+ Pain Management and Opioids (IM) only

ABIM CME MOCSuccessful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 10 MOC points and patient safety MOC credit in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

American Academy of Family Physicians (AAFP)
NEJM Knowledge+ Pain Management and Opioids (FM) only

This Enduring Material activity, NEJM Knowledge+ Pain Management and Opioids, has been reviewed and is acceptable for up to 10.00 Prescribed credit(s) by the American Academy of Family Physicians. AAFP certification begins 04/03/2019. Term of approval is for one year from this date. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Board of Medical Specialties Maintenance of Certification Part 2 Credit

Through the American Board of Medical Specialties (“ABMS”) ongoing commitment to increase access to practice relevant Continuing Certification Activities through the ABMS Continuing Certification Directory, NEJM Knowledge+ Pain Management and Opioids has met the requirements as an MOC Part II Self-Assessment and/or MOC Part II CME Activity (apply toward general CME requirement) for the following ABMS Member Boards:

MOC Part II Self-Assessment Activity Physical Medicine and Rehabilitation

MOC Part II CME Activity Anesthesiology Family Medicine Preventive Medicine Psychiatry and Neurology Radiology

Royal College of Physicians and Surgeons of Canada

Through an agreement between the Accreditation Council for Continuing Medical Education and the Royal College of Physicians and Surgeons of Canada, medical practitioners participating in the Royal College MOC Program may record completion of accredited activities registered under the ACCME’s “CME in Support of MOC” program in Section 3 of the Royal College’s MOC Program.

NCCPA Accreditation Statement

PAs may claim a maximum of 10 Category 1 credits for completing this activity. NCCPA accepts AMA PRA Category 1 Credit™ from organizations accredited by ACCME or a recognized state medical society.

Credit Information for Nurse Practitioners

For the purposes of recertification, the American Academy of Nurse Practitioners Certification Board (AANPCB) accepts AMA PRA Category 1 Credit(s)™ issued by organizations accredited by ACCME as the number of hours of participation. Documentation of participation to non-physicians specifying the number of hours of participation is provided upon successful completion.

Please note: 1 CME Credit = 60 minutes or 1 contact hour, all of which are pharmacology credit-worthy.

Accreditation Term

Original Release Date: April 3, 2019 Review dates: N/A Termination Date: April 3, 2022

ACPE Credits

ACPE LogoNortheastern University School of Pharmacy is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education.

This application based activity is approved for 8.0 contact hours.

The ACPE universal activity number is: 0027-9999-19-069-H01-P.

The initial release date is July 16, 2019.

The planned expiration date is July 16, 2022.