Question of the Week

For March 9, 2021

A 45-year-old man presents to discuss his uncontrolled type 2 diabetes and obesity (BMI, 33). Since his diabetes diagnosis one year ago, he has taken metformin 1000 mg twice daily and joined a formal weight-loss program, but he has not had any significant weight loss and his most recent glycated hemoglobin level was 7.6%. He is concerned about the long-term risks of uncontrolled hyperglycemia and is therefore motivated to add another antidiabetic agent. He also wants to discuss medications to help him lose weight.

Which one of the following medications would be most effective in helping this patient achieve his dual goals of improving glycemic control and losing weight?

Glipizide
Glimepiride
Pioglitazone
Semaglutide
Repaglinide

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