Learning Objectives

  • Demonstrate an increase in your knowledge of clinical medicine.
  • Evaluate the appropriateness of clinical information as it applies to the care of your patients.
  • Demonstrate an improvement in your ability to make decisions that provide safe and effective medical care.
  • Recognize areas of personal strength and areas for growth in clinical knowledge.

Intended Audience

Physicians, residents, and physician assistants who are seeking to maintain and augment their knowledge in family medicine and/or who are preparing for their initial board certification or recertification.


The Massachusetts Medical Society is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

CME Credit

The Massachusetts Medical Society designates this enduring material for a maximum of 270 AMA PRA Category 1 Credits™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

AAFP Prescribed Credit

This Enduring Material activity, NEJM Knowledge+ Family Medicine Board Review has been reviewed and is acceptable for up to 270.00 Prescribed credits by the American Academy of Family Physicians. Term of credit begins 02/01/2018. Term of approval is for one year from this date. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

AAPA Self-Assessment CME Credit

AAPA Category 1 Self-Assessment CMEThis Self-Assessment CME program has been reviewed and is approved for a maximum of 20.00 AAPA Category 1 Self-Assessment CME credits by the Physician Assistant Review Panel. Approval is valid for one year from the release date of 02/01/2017. Physician Assistants should claim only the credit commensurate with the extent of their participation in the activity. This program was planned in accordance with AAPA’s CME Standards.

Method of Participation

You must answer questions correctly to receive AMA PRA Category 1 Credits™, AAFP Prescribed credits, and AAPA Category 1 Self-Assessment CME credits toward Certification Maintenance.

Six questions answered correctly are designated for 1 AMA PRA Category 1 Credit™, 1 AAFP Prescribed credit, and 1 AAPA Category 1 Self-Assessment CME credit.

CME Accreditation Term

CME credit is available for 3 years. Term begins February 1, 2015.

Individual Disclosures

During their tenure with NEJM Knowledge+, the following planners, authors, and reviewers have disclosed the following relevant financial relationships with an ACCME-defined commercial interest.

Thomas M. Best, MD, PhD
– Consultant for Abbot and ZetrOZ

William Busse, MD
– Advisory board for Merck
– Consultant for Amgen, Novartis, GlaxoSmithKline, MedImmune, and Genentech
– Data monitoring boards for Genentech and Boston Scientific
– Study oversight committee for ICON

Andrew T. Chan, MD
– Consultant for Bayer Healthcare, Pfizer, Pozen, and Millennium Pharmaceuticals
– Speakers bureau for Millennium Pharmaceuticals

Vincent W. Chiang, MD
– Financial interest in AugMI Labs

Kelly M. Cordoro, MD
– Consulting for Anacor Pharmaceuticals

Rajesh T. Gandhi, MD
– Scientific advisory board for Gilead
– Grant support from Tibotec (Janssen Therapeutics), Abbott, and ViiV Healthcare

James E. Gern, MD
– Consultant for Janssen Pharmaceutical Companies of Johnson & Johnson, GlaxoSmithKline, Boehringer Ingelheim, MedImmune AstraZeneca, and Merck
– Grant support from GlaxoSmithKline and Merck

Emily M. Godfrey, MD, MPH
– Speakers’ bureaus for Merck Pharmaceuticals and Bayer Women’s Health
– Consultant for Teva Women’s Health

Jason Robert Gotlib, MD
– Clinical trial research funding from Novartis, Promedior, Incyte, CTI Biopharma, Gilead, Seattle Genetics, and Pharmacyclics
– Study steering committee member, advisory board member, and receipt of honoraria from Novartis
– Advisory board member and receipt of honoraria from Incyte

Elizabeth Harrison, MD
– Financial interest in Pfizer, Merck, and Express Scripts

Simon M. Helfgott, MD
– Consultant for AbbVie and Genentech

James V. Hennessey, MD
– Consultant for Akrimax and AbbVie

Amel Karaa, MD
– Grant support, consulting fees, and honoraria from Sanofi Genzyme
– Grant support and consulting fees from Shire and Stealth Biotherapeutics
– Consulting fees from Akros Pharma, Concert, Alexion, and Lumleian
– Grant support from Reata Pharmaceuticals and Protalix Biotherapeutics

Eli Miloslavsky, MD
– Fellowship in 2012–2013 from Genentech

Paul A. Monach, MD
– Grant support from Genentech

Christopher J. Moran, MD
– Grant support from Allergan

Alan C. Moss, MD
– Consultant for Janssen Pharmaceutical Companies of Johnson & Johnson,Theravance Biopharma, Seres Therapeutics, and Boehringer Ingelheim
– Grant research/support from Pfizer

Leigh C. Reardon, MD
– Speakers bureau for Actelion

Misha A. Rosenbach, MD
– Consultant for Celgene

Paul E. Sax, MD
– Consultant for Bristol-Myers Squibb, GlaxoSmithKline, Merck, Janssen Pharmaceutical Companies of Johnson & Johnson, and Gilead
– Grant support from Bristol-Myers Squibb, GlaxoSmithKline, Merck, and Gilead

Marvin I. Schwarz, MD
– Consultant for Boehringer Ingleheim, InterMune, and Merck

Bradford Shingleton, MD
– Consultant for Transcend Medical
– Grant research/support from Alcon

John I. Takayama, MD, MPH
– Financial interest in Omnicell

Derrick J. Todd, MD, PhD
– Consultant for Genentech and Regeneron

Avram Z. Traum, MD
– Consultant for Alexion Pharmaceuticals

Andrew A. Wagner, MD
– Consultant for BK ultrasound

James L. Zehnder, MD
– Grant research/support from Novartis

None of the other individuals in a position to control the activity have any relevant financial relationships with commercial interests to report. The complete list of contributors can be found here.

Conflict of Interest Resolution

The Department of Continuing Education and Certification (DCEC) of the Massachusetts Medical Society has reviewed the appropriate documentation provided by the above planners, authors, and reviewers. Any potential conflicts of interest have been identified and resolved using DCEC processes for conflict management and resolution. For more information about DCEC processes for COI management, please contact the DCEC at continuingeducation@mms.org.

Disclosure of Commercial Support

No commercial support was received for this activity.

Medium or Combination of Media Used

This is an adaptive self-assessment tool designed to adjust to the learner’s strengths and areas for growth, and can be accessed from a desktop, laptop, tablet, or smartphone. Learners choose the subspecialty area and are presented with a sequence of questions. After each question is answered, the user is provided with the key learning point, detailed feedback that discusses the correct answer as well as each of the wrong answers, and citations to relevant articles.

Estimated Time to Complete the Educational Activity

One hour for every 6 questions answered correctly.


Each clinical vignette includes citations and references.

Hardware/Software Requirements


  • Google Chrome 30+, Safari 5.0+, Internet Explorer 11.0+, Mozilla Firefox 10.0+, Microsoft Edge
    Recommended: Google Chrome 39+, Safari 7+, Internet Explorer 11, or Firefox 32+
  • Windows 7 (32-bit and 64-bit), Windows 8+. Windows 7+ is recommended.
  • Minimum 1 GB of RAM but 2 GB or greater is recommended
  • 2.33 GHz or faster x86-compatible processor, or Intel® Atom™ 1.6 GHz or faster processor for netbooks
  • Display resolution: 1024 × 768 or better

Mac OS

  • Google Chrome 14+, Safari 5.0+, Mozilla Firefox 12.0+
    Recommended: Google Chrome 39+, Safari 7+, or Firefox 32+
  • Mac OS X v10.6+
  • Minimum 1 GB of RAM but 2 GB or greater is recommended
  • Intel Core™ Duo 1.33GHz or faster processor
  • Display resolution: 1024 × 768 or better


NEJM Knowledge+ apps are available for iOS and Android smartphones and tablets; Android phones may access NEJM Knowledge+ through our mobile-optimized browser version.

  • iOS devices running OS 8+(includes iPhone and iPad devices).
  • Android version 4+ (includes smartphones and tablets). Android version 5+ is recommended. Note: Android phones will also support the browser version of each product (Chrome recommended).

Contact Information

For all questions and comments, please contact NEJM Knowledge+ by email at knowledgeplussupport@nejm.org or call toll-free 855-318-9303 (within the USA and Canada) or 781-434-7998.

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